A case of anti-NMDA receptor encephalitis in a woman with a NMDA-R+ small cell lung carcinoma (SCLC)

Publication date: Available online 25 March 2016
Source:Clinical Immunology
Author(s): M. Jeraiby, A. Depincé-Berger, V. Bossy, J.C. Antoine, S. Paul
The association of small cell lung cancer with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is rare. We report a 62 year old patient who developed psychiatric disorders followed by epilepsy, movement disorders, mutism and hypoventilation. Flair weighted brain MRI sequences showed diffuse high signals in the limbic system. Anti-NMDAR antibodies were detected in the serum and CSF. The patient's IgGs reacted with the patient's own tumor cells and with 2 out of 4 small cell lung cancers of patients without neurological syndrome.



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