Central Giant Cell Granuloma of the Mandible Requiring Multiple Treatment Modalities – A Case Report

Publication date: Available online 27 February 2016
Source:Journal of Oral and Maxillofacial Surgery
Author(s): David Jerkins, Maximilian Malotky, Reza Miremadi, Mukund Dole
Central giant cell granuloma (CGCG) is a relatively rare non-neoplastic, intraosseous lesion which exhibits a wide spectrum of clinical behavior and its management can be particularly challenging even for experienced clinicians. The etiopathogenesis of this disease process remains unclear, although factors such as trauma, inflammatory foci and a genetic predisposition have been implicated. While multiple treatment modalities have been used with varying degrees of success, there is no accepted algorithm for therapeutic intervention and little is known about the reasons for success or failure of a given treatment. This paper reviews the epidemiology, presentation, classification, and currently used therapies for CGCG, while describing the clinical course and successful therapeutic outcome of a young female with an aggressive CGCG of the mandible.



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