MBL2 polymorphisms and the risk of asthma

Publication date: Available online 30 August 2016
Source:Annals of Allergy, Asthma & Immunology
Author(s): Jing Shi, Xianying Zhu, Min Xie, Jianmiao Wang, Yuanzhou He, Yongjian Xu, Xiansheng Liu
BackgroundThe association between MBL2 gene polymorphisms and the risk of asthma has been evaluated in multiple studies; however, the results are inconsistent.ObjectiveTo perform a meta-analysis to explore whether MBL2 gene polymorphisms were associated with the risk of asthma.MethodsWe searched PubMed, Web of Science, and Cochrane Library to find relevant articles published up to March 2016. Nine studies, including 2066 cases and 2183 controls, were included in the meta-analysis. The strength of association was evaluated by odds ratio (OR) with 95% confidence interval (CI).ResultsThe results reveal that MBL2 gene polymorphisms (codon 54 A/B, –550 H/L or –221 X/Y) were not associated with the risk of asthma (codon 54 A/B: BB+AB vs AA: OR, 1.02; 95% CI, 0.85–1.23; –550 H/L: LL+HL vs HH: OR, 0.81; 95% CI, 0.63–1.03; –221 X/Y: XX+YX vs YY: OR, 0.85; 95% CI, 0.69–1.04). Subgroup analysis by ethnicity implied that the MBL2 codon 54 A/B polymorphism was not significantly associated with the risk of asthma in Asians (BB+AB vs AA: OR, 0.95; 95% CI, 0.70–1.29) or whites (BB+AB vs AA: OR, 1.07; 95% CI, 0.84–1.35).ConclusionThe results indicated that MBL2 gene polymorphisms (codon 54 A/B, –550 H/L or –221 X/Y) may be not associated with the risk of asthma.



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