StatPearls

StatPearls

Book. 2017 06

Authors:

Abstract
Doxorubicin (Adriamycin) is an antibiotic derived from the Streptomyces peucetius bacterium. It has been widely used as a chemotherapeutic agent since the 1960s. Doxorubicin is part of the anthracycline group of chemotherapeutic agents; other anthracyclines include daunorubicin, idarubicin, and epirubicin. Commonly, doxorubicin is used in the treatment of solid tumors in adult and pediatric patients. Doxorubicin may be used to treat soft tissue and bone sarcomas as well as cancers of the breast, ovary, bladder, and thyroid. It is also used in the treatment of acute lymphoblastic leukemia, acute myeloblastic leukemia, Hodgkin lymphoma, and small cell lung cancer. The liposomal formulation of doxorubicin, Doxil, is FDA-approved for the treatment of ovarian cancer in patients who have failed platinum-based chemotherapy, AIDS-related Kaposi sarcoma, and multiple myeloma.

PMID: 29083582

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