Fishing anti(lymph)angiogenic drugs with zebrafish.

Fishing anti(lymph)angiogenic drugs with zebrafish.

Drug Discov Today. 2017 Oct 25;:

Authors: García-Caballero M, Quesada AR, Medina MA, Marí-Beffa M

Abstract
Zebrafish, an amenable small teleost fish with a complex mammal-like circulatory system, is being increasingly used for drug screening and toxicity studies. It combines the biological complexity of in vivo models with a higher-throughput screening capability compared with other available animal models. Externally growing, transparent embryos, displaying well-defined blood and lymphatic vessels, allow the inexpensive, rapid, and automatable evaluation of drug candidates that are able to inhibit neovascularisation. Here, we briefly review zebrafish as a model for the screening of anti(lymph)angiogenic drugs, with emphasis on the advantages and limitations of the different zebrafish-based in vivo assays.

PMID: 29081356 [PubMed - as supplied by publisher]

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