Cancer risk of lichen planus: a cohort study of 13,100 women in Finland.

Cancer risk of lichen planus: a cohort study of 13,100 women in Finland.

Int J Cancer. 2017 Aug 31;:

Authors: Halonen PM, Jakobsson MI, Heikinheimo MAO, Riska AE, Gissler MV, Pukkala EI

Abstract
The association between lichen planus (LP) and cancer has been under debate for decades. We studied the connection via population-based Finnish register data. All women with the diagnosis of LP (n=13,100) were identified from the Finnish Hospital Discharge Registry from 1969-2012. These patients were linked with subsequent cancer diagnoses from the Finnish Cancer Registry until 2014. Standardized Incidence Ratios (SIRs) were counted for different cancers by dividing the observed numbers of cancers by expected numbers, which were based on national cancer incidence rates. In total, 1,520 women with LP were diagnosed with cancer (SIR 1.15, 95% CI 1.09-1.20). LP was associated with an increased risk of cancer of lip (SIR 5.17, 95% CI 3.06-8.16), cancer of tongue (SIR 12.4, 95% CI 9.45-16.0), cancer of oral cavity (SIR 7.97, 95% CI 6.79-9.24), cancer of oesophagus (SIR 1.95, 95% CI 1.17-3.04), cancer of larynx (SIR of 3.47, 95% CI 1.13-8.10) and cancer of vulva (SIR 1.99, 95% CI 1.18-3.13). The risk of cancer was not increased in other locations where LP manifests (pharynx, skin). Patients with diagnosed LP have an increased risk for developing cancer on the mucosal sites of the upper gastrointestinal tract, larynx and vulva. These data are important when considering treatment and follow-up of patients with LP diagnosis. This article is protected by copyright. All rights reserved.

PMID: 28857160 [PubMed - as supplied by publisher]

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