Axitinib-related osteonecrosis of the jaw.

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Axitinib-related osteonecrosis of the jaw.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Aug 18;:

Authors: Patel V, Sproat C, Kwok J, Tanna N

Abstract
Tyrosine kinase inhibitors (TKIs) are oral chemotherapy drugs used primarily to treat leukemias, renal cell carcinomas, gastrointestinal stromal tumors, and neuroendocrine tumors. Within this group, a number of drugs have already been implicated in jaw necrosis. Axitinib (Inlyta) is a novel TKI currently licensed for the treatment of renal cell carcinoma. We report the first case, to our knowledge, of jaw necrosis solely related to this medication and review the literature surrounding TKIs and their implication in osteonecrosis of the jaw.

PMID: 28918879 [PubMed - as supplied by publisher]

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