The Role of Bone Remodelling in Maintaining and Restoring Bone Health: an Overview

Abstract

Autocrine, paracrine and endocrine signals regulate the activities of cells involved in skeletal remodelling. Mapping of the metabolic pathways of bone cells and characterization of their chemical mediators have prompted the pharmaceutical industry to develop patented drugs and auto-antibodies which modulate the anabolic and catabolic activities in bone. This overview provides insight into the metabolic pathways which govern bone cells involved in bone metabolism as a framework for understanding the progress made in the pharmaceutical manipulation of skeletal health.

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