Topical Mitomycin C application in the treatment of refractory benign esophageal strictures in adults and comprehensive literature review.

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Topical Mitomycin C application in the treatment of refractory benign esophageal strictures in adults and comprehensive literature review.

Dig Liver Dis. 2016 Jun 28;

Authors: Bartel MJ, Seeger K, Jeffers K, Clayton D, Wallace MB, Raimondo M, Woodward TA

Abstract
BACKGROUND: Recurrent complex esophageal strictures remain difficult to manage.
AIMS: To determine the efficacy of topical Mitomycin C application for recurrent benign esophageal strictures.
METHODS: All patients who underwent balloon dilation followed by topical Mitomycin C application for recurrent benign esophageal strictures were included. Primary outcome was number of dilations and change of dysphagia score.
RESULTS: Nine patients with anastomotic (3), radiation-induced (3), caustic (2), and combined anastomotic and radiation-induced (1) strictures were included. Strictures had a mean length of 13.75mm, diameter of 8.0mm, and were dilated 10.7 times over a median of 8 months (1.5 dilations per month). Following Mitomycin C application, the need for further dilation decreased to 0.39 dilations per month over a median of 10 months; however, dysphagia scores improved not significantly from 3.2 to 2.6 (mean).
CONCLUSION: In this pilot study, topical Mitomycin C in conjunction with dilation decreased the frequency of esophageal dilations for recurrent benign esophageal strictures.

PMID: 27443493 [PubMed - as supplied by publisher]

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