Induction of Bcl11b during T cell commitment through a tripartite mechanism

Nature Immunology 17, 903 (2016). doi:10.1038/ni.3520

Author: Katia Georgopoulos

Induction of the transcription factor Bcl11b in early T cell precursors is supported by three positive forces: signaling via the transmembrane receptor Notch1 provides stochastic permissivity; the transcription factors TCF-1 and GATA-3 poise the locus for expression; and the transcription factor Runx1 steps in to raise expression.

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