Δευτέρα 15 Αυγούστου 2022

Dynamic Prediction of Survival for Sinonasal Extranodal Natural Killer/T‐cell Lymphoma

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Dynamic Prediction of Survival for Sinonasal Extranodal Natural Killer/T-cell Lymphoma

This study developed a prognostic model and a web-based calculator specifically focussed on SN-ENKTL for otolaryngologists to use to facilitate timely treatment decisions for the disease.


Background

Extranodal natural killer/ T-cell lymphoma (ENKTL) is a rare malignant tumor. This study aimed to develop a predictive nomogram and a web-based survival rate calculator for dynamically predicting the survival of patients with sinonasal ENKTL (SN-ENKTL).

Methods

This study investigated patients (n = 134) with SN-ENKTL who had been initially treated in our hospital between Jan 2008 and Dec 2016. The patients were randomly divided into training and validation cohorts, in a 7:3 ratio. Independent prognostic factors were identified and integrated to build a predictive nomogram and a web-based calculator using the Cox-regression model. The nomogram was evaluated by consistency index and calibration curve.

Results

Age, lactate dehydrogenase, hemoglobin, Epstein–Barr virus DNA, and Ann Arbor stage were identified as independent risk factors. We constructed a predictive nomogram for survival and a web-based calculator (https://taiqinwang.shinyapps.io/DynNomapp/).

Conclusion

This study developed a prognostic model and a web-based calculator specifically focused on SN-ENKTL for otolaryngologists to use to facilitate timely treatment decisions for the disease.

Level of Evidence

4 Laryngoscope, 2022

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