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Neurocutaneous melanocytosis (melanosis): AbstractNeurocutaneous melanosis (NCM; MIM # 249400; ORPHA: 2481], first reported by the Bohemian pathologist Rokitansky in 1861, and now more precisely defined as neurocutaneous melanocytosis, is a rare, congenital syndrome characterised by the association of (1) congenital melanocytic nevi (CMN) of the skin with overlying hypertrichosis, presenting as (a) large (LCMN) or giant and/or multiple (MCMN) melanocytic lesions (or both; sometimes associated with...
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Severe dimethoate self-poisoning causes a syndrome characterized by marked hypotension with progression to distributive shock and death despite standard treatments. A lack of cardiotoxicity until just before death suggests that the mechanism is of OP-induced low systemic vascular resistance (SVR).Nov 11, 2008Hypotension in Severe Dimethoate Self-Poisoning - NCBICase Report - (2020) Volume 10, Issue 5 Curious Case of Dimethoate Poisoning with Early Onset Intermediate Syndrome, Cardiotoxicity and Hypothermia:...
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Organophosphate Poisoning Complicated by RhabdomyolysisInduced Acute Kidney Injury A Case Report and Review of Literature: JB Gunasena, ST De Silva ABSTRACTBackground: Rhabdomyolysis induced acute kidney injury (AKI) following organophosphate poisoning is a rarecomplication. The mechanism responsible is uncertain.Case report: A 42 years old male was admitted to a tertiary care hospital in Sri Lanka after deliberate self-ingestion ofCalcron® (Profenophos, an organophosphorus pesticide). He developed...
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Effects of partial internal biliary diversion on long-term outcomes in patients with progressive familial intrahepatic cholestasis: experience in 44 patients.: Related ArticlesEffects of partial internal biliary diversion on long-term outcomes in patients with progressive familial intrahepatic cholestasis: experience in 44 patients.Pediatr Surg Int. 2020 May;36(5):603-610Authors: Foroutan HR, Bahador A, Ghanim SM, Dehghani SM, Anbardar MH, Fattahi MR, Forooghi M, Azh O, Tadayon A, Sherafat A, Yaghoobi...
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Biliary ascariasis and severe bacterial outcomes: Report of three cases from a paediatric hospital in Brazil.: Related ArticlesBiliary ascariasis and severe bacterial outcomes: Report of three cases from a paediatric hospital in Brazil.Int J Infect Dis. 2020 Jun;95:115-117Authors: de Almeida BL, Silva DV, do Rosário MS, Gonçalves BSD, Nunes MG, Ney ALCM, Silvany C, de Siqueira ICAbstract INTRODUCTION: Biliary ascariasis, although uncommon, can lead to infectious complications and severe...
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Increasing parenting self-efficacy: The Fussy Baby Network® intervention.: Related ArticlesIncreasing parenting self-efficacy: The Fussy Baby Network® intervention.Infant Ment Health J. 2020 03;41(2):232-245Authors: Gilkerson L, Burkhardt T, Katch LE, Hans SLAbstract High levels of infant crying place families at risk for disrupted relationships, parenting stress, and even for child maltreatment. We conducted an evaluation of the Fussy Baby Network® (FBN), a program supporting families...
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Birth Weight and the Development of Functional Gastrointestinal Disorders in Infants.: Related ArticlesBirth Weight and the Development of Functional Gastrointestinal Disorders in Infants.Pediatr Gastroenterol Hepatol Nutr. 2020 Jul;23(4):366-376Authors: Baldassarre ME, Di Mauro A, Salvatore S, Tafuri S, Bianchi FP, Dattoli E, Morando L, Pensabene L, Meneghin F, Dilillo D, Mancini V, Talarico V, Tandoi F, Zuccotti G, Agosti M, Laforgia NAbstract Purpose: To assess the association between...
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Low prevalence of infantile functional gastrointestinal disorders (FGIDs) in a multi-ethnic Asian population.: Related ArticlesLow prevalence of infantile functional gastrointestinal disorders (FGIDs) in a multi-ethnic Asian population.Pediatr Neonatol. 2020 Aug 16;:Authors: Chew KS, Em JM, Koay ZL, Jalaludin MY, Ng RT, Lum LCS, Lee WSAbstract BACKGROUND: Functional gastrointestinal disorders (FGIDs) are common in children. The prevalence of FGIDs varies across the world but is unknown...
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Plants, Vol. 9, Pages 1350: Identification and Analysis of NBS-LRR Genes in Actinidia chinensis GenomePlants, Vol. 9, Pages 1350: Identification and Analysis of NBS-LRR Genes in Actinidia chinensis Genome Plants doi: 10.3390/plants9101350 Authors: Tao Wang Zhan-Hui Jia Ji-Yu Zhang Min Liu Zhong-Ren Guo Gang Wang Nucleotide-binding site and leucine-rich repeat (NBS-LRR) genes represent the most important disease resistance genes in plants. The genome sequence of kiwifruit (Actinidia chinensis) provides...
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Plants, Vol. 9, Pages 1350: Identification and Analysis of NBS-LRR Genes in Actinidia chinensis GenomePlants, Vol. 9, Pages 1350: Identification and Analysis of NBS-LRR Genes in Actinidia chinensis Genome Plants doi: 10.3390/plants9101350 Authors: Tao Wang Zhan-Hui Jia Ji-Yu Zhang Min Liu Zhong-Ren Guo Gang Wang Nucleotide-binding site and leucine-rich repeat (NBS-LRR) genes represent the most important disease resistance genes in plants. The genome sequence of kiwifruit (Actinidia chinensis) provides...
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Clinical GeneticsExploring genotype‐phenotype relationships in the CDKL5 deficiency disorder using an international datasetABSTRACT Characterised by early‐onset seizures, global developmental delay and severe motor deficits, CDKL5 deficiency disorder is caused by pathogenic variants in the cyclin‐dependent kinase‐like 5 gene. Previous efforts to investigate genotype‐phenotype relationships have been limited due to small numbers of recurrent mutations and small cohort sizes. Using data from the...
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Intralesional methotrexate in dermatology: diverse indications and practical considerations: AbstractIntralesional methotrexate (IL‐MTX) is a long‐established treatment, which is arguablyunderutilized by dermatologists. We describe the underlying evidence base and practical considerations for its broad range of cutaneous indications,including in cutaneous oncology (keratoacanthomas, squamous cell carcinomas, lymphomas), inflammatory dermatology (nail psoriasis, plaque psoriasis, pyoderma gangrenosum,...
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Intralesional immunotherapy for molluscum contagiosum: A review: AbstractMolluscum contagiosum (MC) is a common cutaneous viral infection with no standard treatment. The virus responsible for MC is thought to be cleared by cell mediated immunity (CMI). Intralesional immunotherapy that stimulates CMI has been shown to be an effective treatment for other cutaneous viruses. In this review, we evaluate the efficacy and safety of intralesional immunotherapy in the treatment of MC. Articles met inclusion...
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Standardizing a volume benchmark for cerebrospinal fluids for optimal diagnostic accuracy: AbstractIntroductionCerebral spinal fluid (CSF) cytomorphologic analysis remains the gold standard in the evaluation of malignant leptomeningeal involvement. However, collection of optimal volumes for adequate cytomorphologic evaluation is not standardized. Our study investigated optimal CSF volumes that result in a significant diagnostic result.MethodsA total of 4114 samples were retrospectively identified...
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Adenomatous neuroendocrine tumors of the middle ear (MEANTs) with local invasion and lymph nodes metastasis: A brief report of a rare neoplasm: AbstractAdenomatous neuroendocrine tumors of the middle ear (MEANTs) are very rare neoplasms which are composed of both epithelial and neuroendocrine components. They have mostly bland histology and indolent biological behavior, yet they may recur and metastasize. Here we present a case of MEANT with ipsilateral local brain, bone and nerve invasion and bilateral...
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Management of transmodiolar and transmacular cochleovestibular schwannomas with and without cochlear implantation: AbstractIntroductionHearing rehabilitation with cochlear implants has attracted increasing interest also for patients with cochleovestibular schwannoma. The authors report their experience with the surgical management of tumors with rare transmodiolar or transmacular extension and outcomes after cochlear implantation (CI). MethodsThis retrospective case series included...
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Association of Estrogen Receptor 1 and Tumor Necrosis Factor α Polymorphisms with Temporomandibular Joint Anterior Disc Displacement without Reduction: Objectives. The aim of this study was to investigate the role of ESR1 rs1643821 and TNF-α rs1800629 as potential genetic factors regulating anterior disc displacement without reduction-mediated inflammatory pathway. Background. The temporomandibular joint is a complex synovial joint that allows mandibular movement in three directions. Although temporomandibular...
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Primary Intraosseous Squamous Cell Carcinoma Involving the Jaw Bones: A Systematic Review and Update: AbstractPrimary intraosseous oral squamous cell carcinoma (PIOSCC) is a rare malignant neoplasm that affects the jaws. Despite its aggressive biological behavior, there are no studies that evaluated the clinicopathological features of this tumor and parameters associated with its prognosis. The objective of the present study was to conduct a systematic review of the available data on oral and maxillofacial...
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Lymphocyte predominant Hodgkin lymphoma, antigen‐driven after all?: AbstractNodular lymphocyte predominant Hodgkin lymphoma (NLPHL) was suggested as an entity separate from other types of Hodgkin lymphoma 40 years ago and recognized in the WHO classification in 2001. Based on its relatively benign course with late distant relapses, relation with lymph node hyperplasia with progressively transformed germinal centers, presence of clonal immunoglobulin gene rearrangements with somatic hypermutations...
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SETDB1 promotes gastric carcinogenesis and metastasis via upregulation of CCND1 and MMP9 expression: AbstractSETDB1 is a histone lysine methyltransferase that has critical roles in cancers. However, its potential role in gastric cancer (GC) remains obscure. Here, we mainly investigate the clinical significance and the possible role of SETDB1 in GC. We find that SETDB1 expression is upregulated in GC tissues and its high‐level expression was a predictor of poor prognosis in patients. Overexpression...
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Microglia/macrophages express alternative proangiogenic factors depending on granulocyte content in human glioblastoma: AbstractMyeloid cells are an inherent part of the microenvironment of glioblastoma multiforme (GBM). There is growing evidence for their participation in mechanisms of tumor escape, especially in development of resistance following initially promising anti‐VEGF/VEGFR treatment. Thus, we sought to define the capability of myeloid cells to contribute to the expression of proangiogenic...
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Evaluation of myostatin as a possible regulator and marker of skeletal muscle–cortical bone interaction in adults: AbstractIntroductionBone mass was recently reported to be related to skeletal muscle mass in humans, and a decrease in cortical bone is a risk factor for osteoporosis. Because circulating myostatin is a factor that primarily controls muscle metabolism, this study examined the role of myostatin in bone mass–skeletal muscle mass interactions. MethodsThe subjects were...
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Effect of etelcalcetide on parathyroid hormone secretion by primary hyperparathyroidism patient-derived primary parathyroid cells: AbstractIntroductionEtelcalcetide (Parsabiv®, AMG 416/ONO-5163) is a novel allosteric modulator for the calcium-sensing receptor approved for hemodialysis patients with secondary hyperparathyroidism of uremia. Etelcalcetide reduced parathyroid hormone levels in hemodialysis patients with secondary hyperparathyroidism of uremia in clinical studies. However, its direct...
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The role of immune checkpoint inhibitor therapy in advanced adrenocortical carcinoma revisited: review of literature: AbstractPurposeAdrenocortical carcinoma (ACC) is a rare disease with few therapeutic options. There is an urgency of new effective therapeutic options for these patients. The role of immune checkpoint inhibitors (ICI) in advanced ACC patients is still unclear. MethodsWe conducted a MEDLINE search using the following string: adrenocortical carcinoma and immunotherapy...
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Translational perspectives to treat Epidermolysis bullosa – where do we stand?: AbstractEpidermolysis bullosa (EB) is the prototypical example of genetic skin fragility disorders. Genotypic heterogeneity, modifier genes, epigenetic, biochemical and environmental factors alter and determine pathogenic traits and, ultimately, the wide and striking phenotypic variability in EB. Besides the primary structural‐functional defect, chronic tissue damage with induction and dysregulation of inflammatory pathways...
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Clinical performance of cantilevered resin-bonded fixed partial dentures for single tooth replacement in elderly patients: Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveTo evaluate the clinical performance of cantilevered resin-bonded fixed partial dentures (CRBFPDs) in single tooth replacement in elderly patients at Qingdao Stomatological Hospital.MethodsIn total, 186 CRBFPDs in 153 patients were made from cobalt-chrome alloy. Panavia F 2.0 was used as a...
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Telomerase reverse transcriptase rs2736098 polymorphism is associated with lung cancer: A meta-analysis: Journal of International Medical Research, Volume 48, Issue 10, October 2020. BackgroundA meta-analysis was conducted to determine whether telomerase reverse transcriptase (TERT) rs2736098 polymorphism was related to the incidence of lung cancer.MethodsWe systematically searched the following three electronic databases: PubMed, Embase, and China National Knowledge Infrastructure (CNKI), for relevant...
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Cardiac contractility modulation attenuates structural and electrical remodeling in a chronic heart failure rabbit model: Journal of International Medical Research, Volume 48, Issue 10, October 2020. BackgroundCardiac contractility modulation (CCM) is non-excitatory electrical stimulation for improving cardiac function. This study aimed to evaluate the effects of CCM on structural and electrical remodeling in a rabbit model of chronic heart failure (CHF).MethodsThirty rabbits were randomly divided...
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Imaging of bioluminescent Klebsiella pneumoniae induced pulmonary infection in an immunosuppressed mouse model: Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveTo establish a mouse model of bioluminescent Klebsiella pneumoniae-induced lung infection, under different infection states after pretreatment with various dosages of cyclophosphamide (CTX).MethodsA K. pneumoniae strain carrying the luxCDABE operon was used to infect immunocompetent mice (intraperitoneal...
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Serum oestradiol levels are inversely associated with C-reactive protein levels in premenopausal women, but not postmenopausal women: Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveEpidemiological studies on the association of serum oestradiol levels and inflammatory markers have reported inconsistent and conflicting results. Therefore, we investigated the association between serum oestradiol and high-sensitivity C-reactive protein (CRP) levels in women on...
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Safety and oncological outcomes for large (stage ≥T2b) and locally advanced renal cell carcinoma: comparison between laparoscopic and modified hand-assisted laparoscopic radical nephrectomy: Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveTo compare the operative and oncologic outcomes between hand-assisted laparoscopic radical nephrectomy (HALRN) and laparoscopic radical nephrectomy (LRN) for large (stage ≥T2b) and locally advanced renal cell carcinoma.MethodsWe...
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Risk factors for early postoperative recurrence in single and small hepatitis B virus-associated primary hepatocellular carcinoma: Journal of International Medical Research, Volume 48, Issue 10, October 2020. ObjectiveTo investigate the risk factors of early postoperative recurrence in patients with single and small (≤3 cm) hepatitis B virus-associated primary hepatocellular carcinoma (HBV-HCC).MethodsThis retrospective study analyzed patients with single and small HBV-HCC. All patients were followed...
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Immune dysfunction in MGAT2‐CDG: A clinical report and review of the literature: AbstractGlycosylation is a critical post/peri‐translational modification required for the appropriate development and function of the immune system. As an example, abnormalities in glycosylation can cause antibody deficiency and reduced lymphocyte signaling, although the phenotype can be complex given the diverse roles of glycosylation. Human MGAT2 encodes N‐acetylglucosaminyltransferase II, which is a critical enzyme...
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Cutaneous vasculopathy and microthrombus-related changes including acral and sacral lesions, retiform purpura, livedo reticularis, and cutaneous vasculitisCutaneous Manifestations in Adult Patients with COVID-19 and Dermatologic Conditions Related to the COVID-19 Pandemic in Health Care Workers: AbstractPurpose of ReviewCOVID-19 (coronavirus viral disease 2019), due to the novel SARS-CoV-2, may present with different types of cutaneous manifestations of varying pathophysiology. During the ongoing...
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The Role of Environmental Exposures in Atopic Dermatitis: AbstractPurpose of ReviewAlthough genetic factors clearly play a role in the development of atopic dermatitis (AD), the recent dramatic increase in the prevalence of AD in low- and middle-income countries is not consistent with only a role of genetic factors. These findings strongly suggest that environmental factors may play an important role in the pathogenesis of AD. Recent FindingsWe reviewed the role of gene-environment...
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Strategies for having a more effective and less toxic CAR T-cell therapy for acute lymphoblastic leukemia: AbstractIn the recent years, using genetically modified T cells has been known as a rapid developing therapeutic approach due to the heartwarming results of clinical trials with patients suffering from relapsed or refractory (R/R) hematologic malignancies such as R/R Acute Lymphoblastic Leukemia (R/R ALL). One of these renowned approaches is Chimeric antigen receptors (CARs). CARs are synthetic...
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Mutationssignaturen beim Kopf- und Hals-Tumor: ZusammenfassungHintergrundDie Pathogenese beim Plattenepithelkarzinom der Kopf- und Halsregion (HNSCC, „head and neck squamous cell carcinoma") ist ein komplexer Mehrstufenprozess und resultiert aus der Interaktion von exogenen und endogenen zellulären Prozessen. Jeder Prozess hinterlässt ein charakteristisches Muster an Mutationen auf dem Tumorgenom, eine sog. Tumorsignatur. StudienlageGegenstand aktueller Studien ist es, spezifische...
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Performance assessment of two motion management systems for frameless stereotactic radiosurgery: AbstractBackground/PurposeFrameless stereotactic radiosurgery (SRS) requires dedicated systems to monitor patient motion in order to avoid inaccurate radiation delivery due to involuntary shifts. The purpose of this study is to assess the accuracy and sensitivity of two distinct motion monitoring systems used for frameless SRS. MethodsA surface image-guided system known as optical...
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Custom designed radial forearm free flap for reconstruction of nasomaxillary defects: Report of two cases: AbstractNasal amputation and nasomaxillary defects, need to reconstruct the internal lining, osteochondral structure, and external coating of the nose. Authors report a 70‐year‐old male and a 65‐year‐old female treated for nasomaxillary defects (Brown JS, Shaw RJ. The Lancet Oncology 2010;11:1001–1008) due to squamous cell carcinoma (SCC) where the tip of the nose was preserved. A new custom...
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Spindle Cell Melanoma Presenting as an Ulcer in a Black Diabetic: Background. Melanoma in blacks is uncommon and exceedingly rare in association with a diabetic ulcer. We present a case of a spindle cell melanoma masquerading as a diabetic ulcer. Case Report. A 57-year-old overweight woman presented to The Maria Holder Diabetes Centre for the Caribbean with a nonhealing ulcer of the right heel after being treated by various primary care physicians over the preceding year. Her general and systematic...
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Nummular Headache - a Case Report of a Rare Entity: Abstract Purpose of ReviewThe purpose of this manuscript is to shed light on systematic work-up of a diagnostic challenge such as nummular headache (NH), and to summarize the relevant literature on NH. Recent FindingsThe specific nature of the shape of the pain site is usually characteristic of NH. Multiple modalities of investigation including succinct imaging are necessary to successfully rule out other similar conditions. SummaryA 26-year-old...
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Bleomycin sclerotherapy in lymphangiomas of the head and neck region: a prospective study: Intralesional sclerotherapy for lymphatic malformations (LMs) has become a modality of choice because of the high morbidity and recurrence rates with surgical excision. Traditionally, the macrocystic variant has shown good results with sclerotherapy. This prospective study was performed to evaluate the role of bleomycin sclerotherapy in the management of different radiological variants of LM. A total of 142...
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Adjuvant radiotherapy for endometrial cancer with cervical stromal involvement: A patterns of practice survey in Australia and New Zealand: AbstractIntroductionThe purpose of this study is to describe the patterns of practice in Australia and New Zealand for post‐operative radiotherapy in endometrial cancer with cervical stromal involvement.MethodsA ten‐item survey including five clinical case scenarios in endometrial cancer with cervical stromal invasion was emailed to Royal Australian and New Zealand...
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DDGP vs. SMILE in Relapsed/Refractory Extranodal Natural Killer/T‐cell Lymphoma, Nasal Type: A Retrospective Study of 54 Patients: Extranodal natural killer/T‐cell lymphoma, nasal type (ENKL) is a rare peripheral T‐cell lymphoma that predominantly occurs in Asian and South American populations. The treatment of ENKL has been a challenge for a long time. This study was conducted to compare the clinical efficacy and safety of cisplatin, dexamethasone, gemcitabine, and pegaspargase (DDGP) and methotrexate,...
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Population Pharmacokinetics of Remimazolam in Procedural Sedation With Nonhomogeneously Mixed Arterial and Venous Concentrations: Remimazolam is an ultra‐short acting benzodiazepine under development for procedural sedation and general anesthesia. Population pharmacokinetic analysis (PopPK) was conducted for remimazolam with arterial and venous samples previously, but results were limited by arterial‐venous concentration differences and inaccurate central volume of distribution (V1) estimates. A...
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Evaluation of the Electroglottographic Signal Variability in Organic and Functional Dysphonia: To confirm the data reported in our previous studies on the analysis of the variability of the electroglottographic signal in the pathological voice; to evaluate possible differences in variability between organic and functional pathologies; to identify any distinctive/typical EGG patterns for these pathologies.
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Denosumab induced atypical fracture of free vascularized fibular graft 20 years after tumour reconstruction:
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Renal cell carcinoma metastasis to the maxillary bone successfully treated with surgery after vascular embolization: a case report: Metastasis of renal cell carcinoma to the oral cavity is rare. Renal cell carcinoma metastases are regarded as radioresistant tumors and surgery is recommended. However, since metastatic renal cell carcinoma h...
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Successful Treatment of Driveline Infection with Vacuum-Assisted Closure Therapy and Instillation Therapy: Thorac Cardiovasc Surg Rep 2020; 09: e29-e32DOI: 10.1055/s-0040-1713731Background Driveline infection is a serious complication in left ventricular assist device (LVAD) patients. We report the case of a patient who was successfully treated by combining instillation and vacuum-assisted closure (VAC) therapy. Case Description A 65-year-old LVAD patient presented with recurrent driveline...
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Conservative Treatment of Iatrogenic Ascending Aortic Hematoma Post-Rotablator Coronary Procedure: Thorac Cardiovasc Surg Rep 2020; 09: e47-e50DOI: 10.1055/s-0040-1715431Background Aortic intramural hematoma due to coronary artery dissection is a rare and serious complication during percutaneous coronary intervention. Case Presentation A 78-year-old female patient was admitted for diagnostic coronarography in the context of stable angina. The coronarography showed an asymmetric and significate...
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Genome-enabled inference of functional genetic variants in the face, brain and behavior [NEW RESULTS]: Lake Malawi cichlid fishes exhibit extensive divergence in form and function among closely related species separated by a relatively small number of genetic changes. During the past million years, hundreds of species have diversified along an ecological axis in rock vs. sand habitats. We compared the genomes of rock- and sand-dwelling species and asked which genetic variants in which genes differed...
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The Effect of Pituitary Gland Disorders on Glucose Metabolism: From Pathophysiology to Management: Horm Metab ResDOI: 10.1055/a-1258-8625This review aims to explore, present, and discuss disorders of glucose metabolism implicated in pituitary gland diseases, the appropriate interventions, as well as the therapeutic challenges that may arise. Pituitary pathologies may dysregulate glucose homeostasis, as both the excess and deficiency of various pituitary hormones can affect glucose metabolism. Increased...
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Effect of periosteal reaction in medication-related osteonecrosis of the jaw on treatment outcome after surgery: AbstractIntroductionSurgical treatment in patients with medication-related osteonecrosis of the jaw (MRONJ) is superior to conservative treatment. However, treatment outcome in patients with periosteal reaction (PR) was significantly poorer than that of those without PR. The purpose of this retrospective study was to analyze the pathophysiology and clinical significance of PR in MRONJ....
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A combined approach to correct posterior left ventricular aneurysm, aortic stenosis and coronary artery disease: AbstractIschaemic heart disease and aortic stenosis are potentially life-threatening conditions. A post-infarct left ventricular aneurysm, when combined with the above, is particularly hazardous. We present a case where all three conditions occurred simultaneously and describe the surgical approach undertaken to attempt correction. The patient underwent aneurysmectomy together with aortic...
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Synonymous mutations and the molecular evolution of SARS-Cov-2 origins [NEW RESULTS]: Human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is most closely related, by average genetic distance, to two coronaviruses isolated from bats, RaTG13 and RmYN02. However, there is a segment of high amino acid similarity between human SARS-CoV-2 and a pangolin isolated strain, GD410721, in the receptor binding domain (RBD) of the spike protein, a pattern that can be caused by either recombination...
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Serial circulating tumor DNA in predicting and monitoring the effect of neoadjuvant chemoradiotherapy in patients with rectal cancer: a prospective multicenter study: Purpose: We investigated the value of circulating tumor DNA (ctDNA) in predicting tumor response to neoadjuvant chemoradiotherapy (nCRT), monitoring tumor burden, and prognosing survival in patients with locally advanced rectal cancer (LARC). Experimental Design: This prospective multicenter trial recruited 106 LARC patients for treatment...
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Phase 1 Study of the Efficacy and Safety of Ramucirumab in Combination with Osimertinib in Advanced T790M-Positive EGFR-Mutant Non-Small Cell Lung Cancer: Purpose: We report the final analysis of JVDL (NCT02789345), which examined the combination of the EGFR TKI osimertinib plus the VEGFR2-directed antibody ramucirumab in patients with T790M-positive EGFR-mutant NSCLC. Experimental Design: This open-label, single-arm phase 1 study enrolled patients with EGFR T790M-positive NSCLC, who had progressed...
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Phase I Study of Lysine-Specific Demethylase-1 Inhibitor CC-90011 in Patients With Advanced Solid Tumors and Relapsed/Refractory Non-Hodgkin Lymphoma: PURPOSE: Lysine-specific demethylase 1 (LSD1) is implicated in multiple tumor types and its expression in cancer stem cells is associated with chemoresistance. CC-90011 is a potent, selective, and reversible oral LSD1 inhibitor. We examined CC-90011 in advanced solid tumors and relapsed/refractory (R/R) non-Hodgkin lymphoma (NHL). EXPERIMENTAL DESIGN:...
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Three distinct stroma types in human pancreatic cancer identified by image analysis of fibroblast subpopulations and collagen: Purpose: Cancer-associated fibroblasts have emerged to be highly heterogenous and can play multifaced roles in dictating pancreatic ductal adenocarcinoma (PDAC) progression, immunosuppression and therapeutic response, highlighting the need for a deeper understanding of stromal heterogeneity between patients and even within a single tumor. We hypothesized that image analysis...
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Activity and Safety of Geptanolimab (GB226) for patients with unresectable, recurrent or metastatic alveolar soft part sarcoma: a phase 2 single-arm study: Purpose: Patients with alveolar soft part sarcoma (ASPS) are rare and have few treatment options. We assessed the activity of geptanolimab (GB226), a fully humanized PD-1 antibody, for patients with unresectable, recurrent or metastatic ASPS. Patients and methods: We did this multicentre, single-arm, phase 2 study (Gxplore-005,NCT03623581) in...
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Intratumoral Injection of Clostridium novyi-NT Spores in Patients with Treatment-Refractory Advanced Solid Tumors: Purpose: Intratumorally injected Clostridium novyi-NT (non-toxic; lackingthe alpha toxin), an attenuated strain of C.novyi, replicates within hypoxic tumor regions resulting in tumor-confined cell lysis and inflammatory response in animals, which warrants clinical investigation. Experimental design: This first-in-humanstudy (NCT01924689) enrolled patients with injectable, treatment-refractory...
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Preclinical activity of SAR408701, a novel anti-CEACAM5-maytansinoid antibody-drug conjugate for the treatment of CEACAM5-positive epithelial tumors: Purpose: Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) is a glycoprotein that has limited expression in normal adult tissues, but is overexpressed in carcinomas of the gastrointestinal tract, the genitourinary and respiratory systems, and breast cancer. As such, CEACAM5 is an attractive target for antibody-based therapies designed...
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A cyclin D1-dependent transcriptional program predicts clinical outcome in mantle cell lymphoma: Purpose: Mantle cell lymphoma (MCL) is characterized by the t(11;14)(q13;q32) translocation leading to cyclin D1 overexpression. Cyclin D1 is a major cell cycle regulator and also regulates transcription, but the impact of cyclin D1-mediated transcriptional dysregulation on MCL pathogenesis remains poorly understood. The aim of this study was to define a cyclin D1-dependent gene expression program and...
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A Morphometric Study of Stylomastoid Foramen with Its Clinical Applications: J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1716674Background To prevent damage to the facial nerve while doing surgery and to give facial nerve block by anesthetics near the stylomastoid foramen we should know its distance from the important anatomical landmarks. So, this study aims to study the location of stylomastoid with respect to nearby anatomical landmarks. Materials and Method The study was performed...
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The Longissimus Capitis Insertion as a Superficial Landmark for the Sigmoid Sinus: An Anatomical Study: J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1716890Objective Many external anatomical landmarks have been used for approximating deeper, intracranial structures. Herein, we evaluate the attachment of the longissimus capitis (LC) on the mastoid process as a landmark for the underlying sigmoid sinus. Methods Adult cadavers underwent dissection of the posterior occiput with special attention...
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Advancement of PI3 Kinase Inhibitor Combination Therapies for PI3K-Aberrant Chordoma: J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1716694Objectives Targeted inhibitors of the PI3 kinase (PI3K) pathway have shown promising but incomplete antitumor activity in preclinical chordoma models. The aim of this study is to advance methodology for a high-throughput drug screen using chordoma models to identify new combination therapies for chordoma. Study Design Present work is an in vitro study....
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Effects of Preoperative Embolization on Juvenile Nasopharyngeal Angiofibroma Surgical Outcomes: A Study of the Kids' Inpatient Database: J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1716676Objectives The aim of the study is to evaluate the effect of preoperative vascular embolization (PVE) on juvenile nasopharyngeal angiofibroma (JNA) surgical outcomes using a national pediatric hospitalization database. Methods The health care cost and utilization project Kids' Inpatient Database was...
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Management of Cutaneously Exposed Carotid Stents in Recurrent and Unresectable Head and Neck Cancer: J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1716692Objective Carotid blowout syndrome (CBS) is a rare but potentially life-threatening complication of head and neck cancer (HNC) treatment. Patients with CBS are managed with covered stents, limited published information exists regarding the management of delayed complications, specifically cutaneous exposure of stents. Here, we present our experience...
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Neurocutaneous melanocytosis (melanosis)Abstract...
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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