Πέμπτη 26 Απριλίου 2018

Effects of Electrical Stimulation of the Rat Vestibular Labyrinth on c-Fos Expression in the Hippocampus.

Effects of Electrical Stimulation of the Rat Vestibular Labyrinth on c-Fos Expression in the Hippocampus.

Neurosci Lett. 2018 Apr 22;:

Authors: Hitier M, Sato G, Zhang YF, Besnard S, Smith PF

Abstract
Several studies have demonstrated that electrical activation of the peripheral vestibular system can evoke field potential, multi-unit neuronal activity and acetylcholine release in the hippocampus (HPC). However, no study to date has employed the immediate early gene protein, c-Fos, to investigate the distribution of activation of cells in the HPC following electrical stimulation of the vestibular system. We found that vestibular stimulation increased the number of animals expressing c-Fos in the dorsal HPC compared to sham control rats (P ≤ 0.02), but not in the ventral HPC. c-Fos was also expressed in an increased number of animals in the dorsal dentate gyrus (DG) compared to sham control rats (P ≤ 0.0001), and to a lesser extent in the ventral DG (P ≤ 0.006). The results of this study show that activation of the vestibular system results in a differential increase in the expression of c-Fos across different regions of the HPC.

PMID: 29694841 [PubMed - as supplied by publisher]



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