Mechanisms and Function of Autophagy in Intestinal Disease.

Mechanisms and Function of Autophagy in Intestinal Disease.

Autophagy. 2017 Nov 13;:0

Authors: Lassen KG, Xavier RJ

Abstract
The discovery of numerous genetic variants in the human genome that are associated with inflammatory bowel disease (IBD) has revealed critical pathways that play important roles in intestinal homeostasis. These genetic studies have identified a critical role for macroautophagy/autophagy and more recently, lysosomal function, in maintaining the intestinal barrier and mucosal homeostasis. This review highlights recent work on the functional characterization of IBD-associated human genetic variants in cell type-specific functions for autophagy.

PMID: 29130415 [PubMed - as supplied by publisher]

from #PM All via ola Kala on Inoreader http://ift.tt/2iWVodk