Technically unresectable recurrent oral cancers: Is NACT the answer?

Surgical excision of loco-regionally recurrent head and neck cancers is associated with a median disease free survival of 17.9months [1]. The utility of surgical excision is limited to stage I–II patients; only very few of recurrent head and neck cancer patients can undergo resection [2]. When surgical salvage is not possible, re-irradiation is the next option. However, patients with locally advanced technically unresectable disease (T4a and T4b) are unlikely to be candidates for re-irradiation.

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