Perspectives on Polycystic Ovary Syndrome: Is Polycystic Ovary Syndrome Research underfunded?

Perspectives on Polycystic Ovary Syndrome: Is Polycystic Ovary Syndrome Research underfunded?

J Clin Endocrinol Metab. 2017 Sep 19;:

Authors: Brakta S, Lizneva D, Mykhalchenko K, Imam A, Walker W, Diamond MP, Azziz R

Abstract
Context: The Polycystic Ovary Syndrome (PCOS) is a common endocrine-metabolic abnormality with a worldwide prevalence of 4%-21%, depending on diagnostic criteria. The National Institutes of Health (NIH) is the largest single funding agency in the world, invests nearly $30.0 billion annually in biomedical research.
Evidence Acquisition: Utilizing the NIH RePorter system we searched for all grants awarded by the NIH for PCOS and three other disorders with comparable degrees of morbidity, and similar or lower mortality and prevalences (i.e. Rheumatoid Arthritis [RA], Tuberculosis [TB], and Systemic Lupus Erythematosus [SLE]).
Evidence Synthesis: We compared funding by the NIH for PCOS, RA, TB, and SLE research for the years 2006 to 2015, inclusive.
Conclusion: PCOS, compared to RA, TB, and SLE, was relatively less funded (total mean 10-year funding was $215.12M vs. $454.39M, $773.77M, and $609.52M, respectively). Funding for PCOS was largely provided by one NIH institute vs. at least two institutes for SLE and RA; and more individual Research Project Grants were awarded to RA, SLE and TB, than PCOS, while PCOS funding was more likely to be through General Clinical Research Centers Program or Specialized Centers Program awards. Our data suggests that PCOS research may be underfunded considering its prevalence, economic burden, metabolic morbidity and negative impact on quality of life. Greater education of NIH leaders, including those at the NHLBI and NIDDK, other federal and state Agency leads, our elected leaders, and the general public, by professional societies, the scientific community, and patient advocates regarding this disorder is needed.

PMID: 29092064 [PubMed - as supplied by publisher]

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