Mitochondria-centric Review of Polyphenol Bioactivity in Cancer Models.

Mitochondria-centric Review of Polyphenol Bioactivity in Cancer Models.

Antioxid Redox Signal. 2017 Oct 30;:

Authors: Stevens JF, Revel JS, Maier CS

Abstract
SIGNIFICANCE: Humans are exposed daily to polyphenols in milligram-to-gram amounts through dietary consumption of fruits and vegetables. Polyphenols are also available as components of dietary supplements for improving general health. Although polyphenols are often advertised as antioxidants to explain health benefits, experimental evidence shows that their beneficial cancer preventing and controlling properties are more likely due to stimulation of pro-oxidant and pro-apoptotic pathways. Recent Advances: The understanding of the biological differences between cancer and normal cell, and especially the role that mitochondria play in carcinogenesis, has greatly advanced in recent years. These advances have resulted in a wealth of new information on polyphenol bioactivity in cell culture and animal models of cancer. Polyphenols appear to target oxidative phosphorylation and regulation of the mitochondrial membrane potential, glycolysis, pro-oxidant pathways, and antioxidant (adaptive) stress responses with greater selectivity in tumorigenic cells.
CRITICAL ISSUES: The ability of polyphenols to dissipate the mitochondrial membrane potential (Δψm) by a protonophore mechanism has been known for more than 50 years. However, researchers focus primarily on the down-stream molecular effects of Δψm dissipation and mitochondrial uncoupling. We argue that the physico-chemical properties of polyphenols are responsible for their anti-cancer properties by virtue of their protonophoric and pro-oxidant properties rather than their specific effects on down-stream molecular targets.
FUTURE DIRECTIONS: Polyphenol-induced dissipation of Δψm is a physico-chemical process that cancer cells cannot develop resistance against by gene mutation. Therefore, polyphenols should receive more attention as agents for co-therapy with cancer drugs to gain synergistic activity.

PMID: 29084444 [PubMed - as supplied by publisher]

from #PM All via ola Kala on Inoreader http://ift.tt/2lCWobh