FATNESS AND FITNESS WITH CARDIO-METABOLIC RISK FACTORS IN ADOLESCENTS.

FATNESS AND FITNESS WITH CARDIO-METABOLIC RISK FACTORS IN ADOLESCENTS.

J Clin Endocrinol Metab. 2017 Oct 27;:

Authors: Demmer DL, Beilin LJ, Hands B, Burrows S, Cox KL, Oddy WH, Mori TA

Abstract
Context: The relative importance of fitness and fatness with cardio-metabolic risk factors are uncertain during the crucial developmental stage of late adolescence.
Objective: We aimed to compare the concurrent influences of cardiorespiratory fitness and fatness in relation to cardio-metabolic risk factors in adolescents from the Western Australian Pregnancy Cohort Study.
Design, Setting and Participants: Cross-sectional analysis was performed on 1128 participants with complete blood pressure data and 963 participants with complete blood biochemistry at 17 years of age. Fatness (waist circumference) and cardiorespiratory fitness (PWC170) were assessed as continuous measures to avoid the use of arbitrary cut points. Analyses used linear regression models adjusted for sex and potential lifestyle confounders.
Main Outcome Measure: Cardio-metabolic risk factors.
Results: Fatness was positively associated with systolic BP (coefficient: 0.19; p<0.001; beta coefficient: 0.20), triglycerides (log coefficient: 0.009; p<0.001; beta coefficient: 0.24), LDL-C (coefficient: 0.005; p=0.007; beta coefficient: 0.10) and hs-CRP (log coefficient: 0.05; p<0.001; beta coefficient: 0.35). There were no significant effects of fitness on any of these measures. A positive association between HOMA-IR and fatness (log coefficient: 0.02; p<0.001; beta coefficient: 0.33) was attenuated by fitness (log coefficient: -.0.18; p<0.001; beta coefficient: -0.18). Fatness was inversely associated with HDL-C in both sexes (coefficient: -0.006; p<0.001; beta coefficient: -0.23), while fitness was positively associated with HDL-C only in females (coefficient: 0.08; p=0.03; beta coefficient: 0.15).
Conclusions: The adverse effects of central adiposity seen across a broad range of cardio-metabolic risk factors were only partially ameliorated by fitness in this adolescent population.

PMID: 29088412 [PubMed - as supplied by publisher]

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