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Influence of polyvinylpyrrolidone, microcrystalline cellulose and colloidal silicon dioxide on technological characteristics of a high-dose Petiveria alliacea tablet.
Drug Dev Ind Pharm. 2017 Aug 01;:1-21
Authors: García-Pérez ME, Lemus-Rodríguez Z, Hung-Arbelo M, Vistel-Vigo M
Abstract
PURPOSE: Petiveria alliacea L. (Phytolaccaceae) is a perennial shrub used by its immunomodulatory, anticancerogenic and anti-inflammatory properties. This study determined the influence of polyvinylpyrrolidone (PVP), colloidal silicon dioxide (CSD) and microcrystalline cellulose (MC) on the technological characteristic of a high-dose P.alliacea tablet prepared by the wet granulation method.
METHODOLOGY: The botanical and pharmacognostic analysis of the plant material was firstly performed, followed by a 2(3) factorial design considering three factors at two levels: a) the binder (PVP) incorporated in formulation at 10 and 15% (w/w); b) the compacting agent (CSD) added at 10 and 15% (w/w) and; c) the diluent (MC) included at 7.33 and 12.46% (w/w). The analysis of pharmaceutical performance and the accelerated and long-term stability of the best prototype was also completed.
RESULT AND DISCUSSION: The binder, compacting agent and the interaction Binder/Diluent had a significant impact on breaking force of high-dose P.alliacea tablet. The optimum formula was found to contain 15% (w/w) of CSD, 7.33% (w/w) of MC and 10% (w/w) of PVP. At these conditions, the tablet shows a breaking force of 77.96 N, a friability of 0.39%, a total phenol content of 1.30 mg/tablet and a maximum disintegration time of 6 min.
CONCLUSIONS: The use of adequate amounts of PVP, MC and CSD as per the factorial design allowed the preparation of a tablet suitable for administration, despite the inappropriate flow and compressibility properties of the P.alliacea powder.
PMID: 28762858 [PubMed - as supplied by publisher]
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